Platelets in Atherothrombosis

Lipoproteins, platelets and atherothrombosis.

Atherosclerosis and thrombosis associated with the rupture of vulnerable plaque are the main causes of cardiovascular events, including acute coronary syndrome. Low-density lipoprotein (LDL) plays a key role in the pathogenesis of atherothrombotic processes. LDLs modify the antithrombotic properties of the vascular endothelium and change vessel contractility by reducing the availability of endo...

Platelets in Atherogenesis and Atherothrombosis

Significance Platelets are unique anucleate blood cells produced by megakaryocytes that, in addition to being the primary effectors of hemostasis, are rapid responders to injury and infection. Therefore, platelets have a diverse functional repertoire in their ability to regulate inflammation, host defense, and tissue repair. This review highlights some of the recent ATVB publications regarding ...

Title : Platelets , atherothrombosis , and atherosclerosis

Platelet microparticles: reinforcing the hegemony of platelets in atherothrombosis.

Microparticles (MPs) represent a heterogeneous population of vesicles with a diameter of 100 to 1,000 nm that are released by budding of the plasma membrane (ectocytosis) and express antigens specific of their parental cells (1). Generation and release of MPs occurs not only during cellular activation following stimulation with proinflammatory, prothrombotic or proapoptotic substances or exposu...

Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells

Visceral obesity is a relevant pathological condition closely associated with high risk of atherosclerotic vascular disease including myocardial infarction and stroke. The increased vascular risk is related also to peculiar dysfunction in the endocrine activity of adipose tissue responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic...